| abstract |
The present invention relates to a molecular signature of pigment spots on the skin, comprising the MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2 genes, and various applications of this signature. The invention relates in particular to a method for characterizing an apparent or suspected pigment spot in a human being, which comprises comparison of the levels of expression, in samples of skin taken from said spot and of non-lesioned adjacent skin, of at least one dermal gene related to matrix remodelling or to the extracellular proteoglycan and glycoprotein components thereof, chosen from the list consisting of the MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2 genes. The invention also relates to methods for evaluating the efficacy of a treatment for pigment spots, to cosmetic and therapeutic methods for treating pigment spots, and also to various modulators of said genes and the use thereof. |