http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2698108-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-055 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-055 |
| filingDate | 2012-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2698108-A1 |
| titleOfInvention | Modification of the Axonal Microstructure in a Mouse Model of Mild Traumatic Brain Injury |
| abstract | The present invention relates to a method of screening for a compound decreasing axonal injury, comprising the steps of (a) exposing the head of a non-human mammal to a pressure of 12 to 17 psi in a shock tube for a time t 2 calculated by the formula t 2 = m 1 / m 2 - 1 / 3 x t 1 , wherein m 2 is the weight of the brain of the non-human mammal, m 1 is 480 mg and t 1 is 1.0 to 2.0 msec, (b) administering a test compound to the non-human mammal obtained in (a), and/or (b') administering a test compound to the non-human mammal before step (a), and (c) measuring the fractional anisotropy in the brain of the non-human mammal by diffusion tensor imaging after performing steps (a) and (b), or (a) and (b'), or (a), (b) and (b'), wherein a test compound is a compound decreasing axonal injury if (i) in the case of (b) and/or (b'): the fractional anisotropy measured in step (c) is increased as compared to the fractional anisotropy measured in the brain of a control non-human mammal of the same species which has been exposed to pressure as defined in step (a), and/or (ii) in the case of (b): the fractional anisotropy measured in step (c) is increased as compared to the fractional anisotropy measured in the brain of said non-human mammal after step (a) and before the administration of the test compound in step (b). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113156351-A |
| priorityDate | 2012-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.