| abstract |
Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X 1 , X 2 , X 3 , and X 4 represents N or N-oxide and the rest thereof are the same or different and each represent C-R 2 ; nany one or two of Y 1 , Y 2 , Y 3 , and Y 4 represent C-R 4 and the rest thereof are the same or different and each represent CH or N; nR 1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O; nR 2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; nR 3 represents a hydrogen atom, -CO-R 5 etc.; nR 4 represents a hydrogen atom, -CO-R 6 , -N(R 7 )(R 8 ) etc.; nR 5 represents a hydroxyl group, an amino group etc.; nR 6 represents a hydroxyl group etc.; nR 7 and R 8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; and R 9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc. |