http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2656079-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_577821cf81fda3e1088e6ed08bcd136b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B15-30 |
| filingDate | 2011-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5e252e994242474c746af5e36748ea7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8241f482409ac15c6ed655727b2f7de |
| publicationDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2656079-A2 |
| titleOfInvention | Crystal structure of flt3 ligand-receptor complex |
| abstract | The present invention relates to the crystal structure of Flt3 and its cognate ligand FL. In particular, the binding interface of Flt3 and its cognate ligand FL has been determined. The present invention also relates to the applicability in modulating Flt3 activity. Methods for the identification as well as the rational design of mediators of Flt3 signaling are disclosed. In an aspect the method comprises a step of employing the atomic coordinates representing the three-dimensional structure of Flt3 and/or FL. In another aspect, the method comprises a step of contacting a candidate ligand with an Flt3 polypeptide comprising the FL binding site or alternatively an FL polypeptide comprising the Flt3 binding site, after which binding is determined |
| priorityDate | 2010-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.