| abstract |
The present application relates to methods for reducing growth of a fungus having a coordination complex formed at the C-terminus of its dicer (dicer 1, ribonuclease type III) between a cation and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe (fission yeast) comprising the step of contacting a fungal cell with an effective amount of an agent, wherein said agent disrupts the coordination complex formed at the C-terminus of fungal dicer between a cation and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe. |