| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26b2ef5cf79757438bb5e2bb1dce0946 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-015 |
| filingDate |
2011-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_659a487c24d3d5288b82a5dbbaf725c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c82756fe8b5e5b3038be59fdf343064a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0e30812ddc92c4917508f44086756d0 |
| publicationDate |
2013-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2624862-A1 |
| titleOfInvention |
Methods and compositions for inducing a t-cell response to plasmodium species |
| abstract |
The present invention relates to methods of inducing a T-cell response against a Plasmodium species antigen in a subject. These method comprise administering to a subject a composition comprising a bacterium which expresses one or more immunogenic polypeptides, the amino acid sequence of which comprise one or more amino acid sequences derived from wild- type Plasmodium LSA1, CelTOS, CSP, and/or TRAP sequences, wherein said amino acid sequences are derived by (i) codon optimization of the wild-type sequence for expression in said bacterium, (ii) deletion of at least one hydrophobic region present in the wild-type sequence, and/or (iii) in the case of LSA1 and CSP, minimization of repeat units present in the wild- type sequence. |
| priorityDate |
2010-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |