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publicationDate 2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2621909-A1
titleOfInvention Process for preparing bosentan monohydrate and its intermediates
abstract The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert- butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)- pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.
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