| abstract |
The present application relates to novel derivatives of monomethyl auristatin F which are substituted at the N-terminus with a carboxyalkyl group, to a method for producing said derivatives, to the use of said derivatives for treating and/or preventing diseases, and to the use of said derivatives for producing pharmaceuticals for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases, such as cancers. Such treatments can be carried out as monotherapy or in combination with other pharmaceuticals or additional therapeutic measures. |