| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5930ed2292d797612e6caf1133d1e4b |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-14 |
| filingDate |
2011-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9946396fc018978ef959ce4b92fc2b7 |
| publicationDate |
2013-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2606020-A2 |
| titleOfInvention |
Method of synthesis of substituted hexitols such as dianhydrogalactitol |
| abstract |
The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t- butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. |
| priorityDate |
2010-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |