http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2595957-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df4b3d8e11e0c4b90a31f109b0f2a8bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0df92bb89f9b9db03895f444856aa9a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e36b5a44fae22b7f49d2b226e8540a0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2996b1e8175f4cafab4956baa7d5509e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3d6acffc8d0564168e8bf026a335fef |
| publicationDate | 2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2595957-A1 |
| titleOfInvention | Pyridin- 2 - yl sulfanyl acid esters and process for the preparation thereof |
| abstract | The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HUVEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS-Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure la, R 1 = H, R 2 = H, R 3 = CH2COOC5H 11 ) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice. |
| priorityDate | 2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.