http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2580230-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1089 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1034 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate | 2011-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c32ead23f3de531ebdbce50e48d4b13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f077124abf4175f270159ccc828d1f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab8de9d5def9a1c0f41411fbe80472a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4821edd8494aa4335625c8b7fa91278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d0177efc9fbfd45a67d6abb89cf0159 |
| publicationDate | 2013-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2580230-A2 |
| titleOfInvention | Compositions and methods for protein production |
| abstract | The present invention provides a method of selecting a mRNA for production of a polypeptide of interest comprising: a) producing an array of individual mRNA sequences comprising different nucleotide sequences encoding the polypeptide of interest; b) determining one or more or two or more of the following parameters for each individual mRNA sequence of (a): (i) minimum free energy (MFE) RNA secondary structure; (ii) ensemble free energy (EFE); (iii) frequency of the minimum free energy (FMFE) RNA secondary structure in a thermodynamic ensemble; and (iv) ensemble diversity (ED); c) ranking the individual mRNA sequences of the array according the parameters determined in step (b); and d) selecting a mRNA sequence from the ranked array of step (c), wherein the selected mRNA produces the polypeptide of interest. The present invention further provides a method of selecting a mRNA for enhanced and reduced production of a polypeptide of interest. |
| priorityDate | 2010-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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