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filingDate 2011-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2013-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2575867-A1
titleOfInvention Novel interferon-alpha-producing bone marrow dendritic cells
abstract A novel dendritic cell type has been identified within bone marrow, termed myelos interferon dendritic cells (miDC). These novel cells possess the high IFN-alpha producing activity of pDC, but they also display a wide TLR responsiveness along with T-cell stimulation capacities that more closely resemble the conventional DC populations. Moreover, these cells appear less prone to apoptosis upon activation stimuli, including viruses. These cells constitute a novel bone marrow innate immune cell type, ideally geared to linking innate and adaptive immune responses via their potent IFN-alpha production and high T-cell stimulatory capacity.
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