| abstract |
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein R 1 is CN; R 2 is H or F; R 3 and R 4 are independently hydrogen, fluorine, chlorine or OR 8 ; R 5 is hydrogen, C 1-6 alkyl, C 1-6 alkenyl or C 1-6 alkynyl; R 6 and R 7 are independently hydrogen, halogen, OR 8 or NR 9 R 10 ; R 8 is hydrogen or C 1-6 alkyl; R 9 and R 10 are independently hydrogen or C 1-6 alkyl; or the groups R 9 and R 10 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR 8 , S and O said 5 or 6 membered ring being optionally substituted by hydroxyl or C 1-6 alkoxy; or the groups R 9 and R 10 when they are attached to a nitrogen atom may together form an azetidinyl ring optionally substituted by hydroxyl or C 1-6 alkoxy, is provided. The use of such compounds in treating amyloid-related disease is also disclosed. |