http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2569293-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bf7d32094a14bb34f5f37b71e1f718a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 |
| filingDate | 2011-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bad7cf0b89ccfa2b89c71cb4ba79bebd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d3bf54f7a11589678bafe9ebd12f7b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39774ef85722c858848a9d8ffb1ac79e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_988a8c869a06adbbdec5bbf3a9e8791a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6543ce6a4073cda7eff9db0578cdf791 |
| publicationDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2569293-A1 |
| titleOfInvention | Pyrazolopyridines as inhibitors of the kinase lrrk2 |
| abstract | A compound of formula la or formula lb, or a pharmaceutically acceptable salt or ester thereof, wherein R 1 is selected from: aryl; heteroaryl; -NHR 3 ; fused aryl-C 4-7 -heterocycloalkyl; - CONR 4 R 5 ; -NHCOR 6 ; -C 3-7 -cycloalkyl; -0-C 3-7 -cycloalkyl; -NR 3 R 6 ; and optionally substituted -C 1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C 4-7 -heterocycloalkyl and C 4-7 - heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; R 2 is selected from hydrogen, aryl, C 1-6 -alkyl, C 2-6 -alkenyl,C 3-7 -cycloalkyl, heteroaryl, C 4-7 heterocycloalkyl and halogen, wherein said C 1-6 -alkyl,, Cz-B-alkenyl, aryl, heteroaryl and C 4-7 -heterocycloalkyl are each optionally substituted;R 3 is selected from aryl, heteroaryl, C 4-7 -heterocycloalkyl, C 3-7 - cycloalkyl, fused aryl-C-heterocycloalkyl and C 1-6 -alkyl, each of which is optionally substituted; R 4 and R 5 are each independently hydrogen, or optionally substituted C 3-7 - cycloalkyl, aryl, heteroaryl, C 1-6 -alkyl or C 3-6 -heterocycloalkyl; or R 4 and R 5 together with the N to which they are attached form a C 3-6 -heterocycloalkyl ring; each R 6 is independently selected from C 1-6 -alkyl, C 3-7 cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each R 7 is selected from hydrogen, optionally substituted C 1-6 -alkyl and C 3-7 -cycloalkyl; each of R 8 and R 9 is independently hydrogen or optionally substituted C 1-6 -alkyl; or R 8 and R 9 together with the N to which they are attached form a C 4-6 -heterocycloalkyl; each R 10 is selected from C 3-7 - cycloalkyl and optionally substituted C 1-6 -alkyl; each R 11 is independently selected from C 1-6 -alkyl, C 3-7 -cycloalkyl, C 1-6 -alkyl-C 3-7 -cycloalkyl, C 4-7 -heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, - NR 4 S0 2 R 5 , -CN, -OR 6 , -NR 4 R 5 , -NR 7 R 11 , hydroxyl, -CF 3 , -CONR 4 R 5 , -NR 4 COR 5 , -NR 7 (CO)NR 4 R 5 , -N0 2 , -C0 2 H, -C0 2 R 6 , -S0 2 R 6 , -S0 2 NR 4 R 5 , -NR 4 COR 5 ,-NR 4 COOR 5 , 6 -alkyl and -COR 6 . Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae la and lb. |
| priorityDate | 2010-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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