http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2565188-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e81931210712a646414043fd669d355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ca6916898b80cc05d9cd927ef85d74e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d99d47b244f4df35f534683975be851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ed14685a4950615950bdde8af7f1f64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9208aee73328581a56aa36544dbbf04b |
| publicationDate | 2013-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2565188-A1 |
| titleOfInvention | Novel photoactivatable paclitaxel derivatives and uses thereof, in particular in cellbiology and cancer treatment |
| abstract | The present invention provides novel photoactivatable paclitaxel derivatives wherein at least the C7 position, preferably both the C2' and C7 positions, of the paclitaxel molecule is/are substituted with a photocleavable moiety such as a chromophore. n Typically, the chromophore is selected from the group comprising 2-nitrobenzyl ethers, carbamates or carbonates and their 4,5-dialkoxy substituted variants; 2-nitrophenylethyl ethers, carbamates or carbonates and their 4,5-dialkoxy substituted variants, or their p-substituted derivatives; α-carboxy-2-nitrobenzyl ethers, carbamates or carbonates and their 4,5-dialkoxy substituted variants; 2(2-nitrophenyl)ethyl ethers, carbamates or carbonates and their 4,5-dialkoxy substituted variants; coumarin-4-ylmethyl ethers, or carbonates and their 7-alkoxy, 6,7-dialkoxy, 6-bromo-7-alkoxy or 7-dialkylamino substituted variants; p-hydroxyphenacyl ethers or carbamates and their meta-substituted derivatives or structurally related compounds. n More specifically, the chromophore is 4,5-dimethoxy-2-nitrobenyloxycarbonyl (Nvoc) or a structurally related compound. n Further aspects of the invention relate to the use of these paclitaxel derivatives in biological, medical and pharmaceutical applications, in particular in cellbiology and cancer treatment. A closely related aspect is an antitumor medicament comprising the above paclitaxel derivatives. |
| priorityDate | 2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.