http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2563408-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_904ec80c3a8ad4a1a00b4e787bd180de http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_297543dd43c5543a05660489b328452f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f54091ce69f577fb027a4b774df1d457 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2982 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-1824 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B82Y5-00 |
| filingDate | 2011-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbe3390a219ac4036b2e9022883f47ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d79bbca29154963abe39169ee768b24d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caec52328ccf86aa85b203d12b4a83ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a97141525c88f8f65370da0a8496d8ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fca85b90af4b764e2cbe4761acd05d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_587d08a0989a1161c0c6c1511879dc04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d69932726d08f13667822587d03b5ff7 |
| publicationDate | 2013-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2563408-A2 |
| titleOfInvention | Ultrafine nanoparticles comprising a functionalized polyorganosiloxane matrix and including metal complexes; method for obtaining same and uses thereof in medical imaging and/or therapy |
| abstract | The invention relates to novel biocompatible hybrid nanoparticles of very small size, that are of use in particular for diagnosis and/or therapy. The objective of the invention is to provide novel nanoparticles which are of use in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which are more effective than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high metal (e.g. rare earth) loading rate, in particular so as to have, in imaging (e.g. MRI), a strong enhancement and a correct response (increased relaxivity) at high frequencies. Thus, the nanoparticles according to the invention, of diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations, optionally associated with doping cations; a DTPABA (diethylenetriaminepentaacetic acid bisanhydride) chelating C1 graft bonded to the POS matrix via -Si-C- covalent bonding, and present in sufficient amount to be able to complex all the gadolinium cations; and optionally an other functionalization graft Gf* bonded to the POS matrix via -Si-C- covalent bonding (it being possible for Gf* to result from a hydrophilic compound (PEG); from a compound comprising an active ingredient AI1; from a targeting compound; from a luminescent compound (fluorescein)). The method for obtaining these nanoparticles and the uses thereof in imaging and in therapy are also part of the invention. |
| priorityDate | 2010-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.