| abstract |
Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I) - (XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free- substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII). |