| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90f4ee566d9768b969cde8b1de75ad0d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 |
| filingDate |
2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_545ea54beb43e131a3a3857fc5882a73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1283188b5223c8973e520aeaa89b2ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbaae007b8916abd309ecf5771bd321e |
| publicationDate |
2013-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2558440-A1 |
| titleOfInvention |
Process for the production of polymorph form i of agomelatine |
| abstract |
The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C 15 H 17 N0 2 Mr = 243.30 Orthorhombic Pca2 1 a = 31.501 (4) Å b = 9.5280 (10) Å c = 17.906 (2) Å Z = 16 the process comprising the process steps of: a) dissolving agomelatine in a solvent to obtain a solution, b) adding the solution to an organic anti-solvent having a temperature of 30°C or below, whereby crystals of the polymorph form I of agomelatine are formed, wherein the solvent of step a) is miscible with the anti-solvent of step b), c) isolating the crystals of the polymorph form I of agomelatine and d) optionally drying the isolated crystals of the polymorph form I of agomelatine. |
| priorityDate |
2010-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |