| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_295309dfb77ee3597f220dd5df49fbba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8217735d5b1c6781d9754cb3ec32a311
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b3b9ba7727b3a54322de1722ecb94db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3eafea4496f52ae8840dfd72f381858d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2c383ea60e9a83b8b116aad136a8622 |
| publicationDate |
2013-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2547337-A1 |
| titleOfInvention |
Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals |
| abstract |
The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called 'clots' and 'flakes' in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarines. A preferred anticoagulant that is used in the methods of the present invention is warfarin. |
| priorityDate |
2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |