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filingDate 2006-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3731cb0ce8b4ffe9b6c2d33da962708
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publicationDate 2013-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2540820-A1
titleOfInvention Means and methods for influencing the stability of antibody producing cells
abstract The invention provides methods for increasing the replicative life span and/or stability of an antibody producing cell, comprising n- providing said antibody producing cell with a compound capable of directly or indirectly enhancing BCL6 expression and/or culturing said antibody producing cell in the presence of a compound capable of directly or indirectly enhancing BCL6 expression; and n- directly or indirectly increasing the amount of Bcl-xL or another anti-apoptotic gene expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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priorityDate 2005-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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