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filingDate 2011-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19bfcc50b80c9e6aa10ae4fd93a968d9
publicationDate 2013-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2539462-A1
titleOfInvention Methods for the detection of biologically relevant molecules and their interaction characteristics
abstract Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings, and measuring the electric current through the holes or the fluorescence near the hole openings. The electric current or fluorescence will change as the molecules diffuse out of the holes, providing a measure of the diffusion rate and thereby detecting the presence and characteristics of the molecules. For molecules that interact, the diffusion rate will be slower than for molecules that do not interact, yielding a determination of the molecular interaction. Capping the population of holes and inserting into a mass spectrometer allows identification of the molecules.
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