http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2522656-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_feef2d2e76e40b47e9cf04aa559bd5ba |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 |
| filingDate | 2004-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db91d399ca2362b480c40bc3d38f5003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09e7dfe3774273eded698b5197bf787c |
| publicationDate | 2013-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2522656-A3 |
| titleOfInvention | Process and Intermediate Compounds Useful in the Preparation of Statins, Particularly Atorvastatin |
| abstract | There is provided a process for the preparation of a compound of formula (7) or salts thereof:n nwherein R 1 represents an alkyl group, R 2 represents an aryl group, R 3 represents an aryl group, and X represents a group of formula -COZ, wherein Z represents -OR 4 or NR 5 R 6 which comprises na) cyanating a compound of formula (1) to give a compound of formula (2); nb) reducing the compound of formula (2) to give a compound of formula (3); nc) coupling the compound of formula (3) with a compound of formula (4) to give a compound of formula (5); nd) when W represents -OP 2 , deprotecting and then oxidising the compound of formula (5) to give a compound of formula (6); and ne) subjecting the compound of formula (5) when W represents =O, or compound of formula (6) to ring-opening, and removal of any remaining protecting groups, to give a compound of formula (7) or salts thereof, nwherein the process comprises the further step of converting X from -COZ, wherein Z represents -OR 4 , to -COZ, wherein Z represents NR 5 R 6 , by reacting the compounds of formula (4), (5), (6) or (7) with a compound of formula HNR 5 R 6 ; and/or nwherein the process further comprises forming a compound of formuIa (2) or (3) wherein W represent =O by oxidising a compound of formula (2) or (3) when W represents -OP 2 and P 2 is hydrogen, or deprotecting and oxidising a compound of formula (2) or (3) when W represents -OP 2 and P 2 is a protecting group. |
| priorityDate | 2003-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.