http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2520934-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f46b9a7a7fb0349640c1efa49a4dba8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dabd0cd4b781bfcaf4b5da9e326a997 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ea1d316477c2b7e1b814ae4dee853a |
| publicationDate | 2012-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2520934-A1 |
| titleOfInvention | Method for finding active pharmaceutical ingredients for the treatment of deseases associated with increased or decreased cytokine pathway activity |
| abstract | The invention relates to a method for finding an active pharmaceutical ingredient suitable for the treatment of a disease associated with increased or decreased cytokine pathway activity, comprising the steps of A1) providing a first lipid profile by a) providing a first cell culture medium comprising a first type of cells, b) stimulating the first type of cells, causing the cells to release a pro-inflammatory cytokine, c) bringing a second type of cells having cytokine receptors In a second cell culture medium Into contact with the cell culture medium of the first type of cells causing the cytokine receptors of the second type of cells to respond to the pro-inflammatory cytokine that is released to obtain a cell culture medium that is in contact with the first and the second type of cells, d) adding a component that is potentially suitable for the prevention, treatment or co-treatment of a disease associated with Increased or decreased cytokine pathway activity to the first cell culture medium and/or to the second cell culture medium and/or to the cell culture medium that is in contact with the first and the second type of cells and e) determining the lipid profiles of the second type of cells and/or of the first type of cells and/or of the cell culture medium that is in contact with the first and the second type of cells to obtain the first lipid profile, A2) providing a second lipid profile by performing step A1) except for sub-step d) to obtain the second lipid profile, B) comparing the first lipid profile to the second lipid profile and C) identifying the component that was added in the method that shows a difference between the first lipid profile and the second lipid profile as the active pharmaceutical Ingredient. |
| priorityDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 200.