http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2518500-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db9a148069e1ac4f5f8790a89287e5c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d65b0d354849084d528a3434f470fd44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbe675b46d686407d64e31a937562663 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2011-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bb4d2cb3e1f5226b1eb45e463e13025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a56f8718eafb804686c7eea9ebc2b808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd61e832974b9192254c242ef0f7d38b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a821d998178c3ec78776b6d6504c4a6e |
| publicationDate | 2012-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2518500-A1 |
| titleOfInvention | In vitro method for determining developmental toxicity of a compound. |
| abstract | The invention is in the field of medical molecular diagnostics. It provides methods and means for the in vitro detection of the developmental toxicity of a compound by determining the gene expression of a limited number of genes. More in particular, it provides a method for determining the developmental toxicity of a compound comprising the steps of providing a 2 - 128 cell stage fish embryo, contacting the fish embryo with the compound, allowing the embryo to develop for an amount of time in the presence of the compound, isolating total RNA from the embryo, determining the expression level of at least one gene selected from the group consisting of cyp26a1, si:rp71-39b20.7, vmhc and hspb12, comparing the expression level of said at least one gene with a predetermined reference value, wherein an increase or decrease of the expression level of said gene indicates that the compound is developmentally toxic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110129433-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110129433-A |
| priorityDate | 2011-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 294.