http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2516384-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd048f86dea957a0403c59240263abcb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08 |
| filingDate | 2010-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3931b391500327acdb4aafe8d93742b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89d9f761491d155aa3b27dd441150e3e |
| publicationDate | 2012-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2516384-A1 |
| titleOfInvention | Novel method for the preparation of (s)-pregabalin |
| abstract | Method for the preparation of a salt (III) of pregabalin and (S)-mandelic acid with a (S, S) diastereomer content greater than 80% which comprises the following steps: (a) Hofmann reaction of (±)-3-(carbamoylmethyl)-5- methylhexanoic acid (I) to obtain racemic pregabalin (II), (b) addition of (S)-(+)-mandelic acid to obtain the corresponding diastereoisomeric salt (III) with a (S, S) diastereomer content greater than 80% (c)optionally, purification of the salt obtained in step (b); characterized in that step(b) is performed without isolating the product obtained in step(a). |
| priorityDate | 2009-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.