http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2497825-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2817954cd008bcd609a4c4eb49050be |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 |
| filingDate | 2011-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bb4f3248329e7f63a0da20d1cf9ae5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79a99f7865ba0faecec64a0b832c497e |
| publicationDate | 2012-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2497825-A1 |
| titleOfInvention | Novel method for rapid and efficient generation of neuroectoderm cells and peripheral neurons from pluripotent stem cells |
| abstract | The present invention relates to a method for generating neuroectoderm cells, the method comprising: culturing pluripotent cells for about 2 to about 6 days, wherein the expression and/or activity of one or more proteins selected from the group consisting of fibroblast growth factor receptor (FGFR), son of sevenless (SOS), growth factor receptor-bound protein 2 (GRB2), rat sarcoma protein (RAS), rat fibrosarcoma (RAF), mitogen-activated protein kinase kinase (MEK) and mitogen-activated protein kinase (MAPK) is inhibited. The present invention further relate to a method for generating neurons, the method comprising the steps for generating neuroectoderm cells in accordance with the invention and culturing the neuroectoderm cells for at least about 2 further days. Furthermore, the present invention also relates to a kit comprising means for inhibiting the expression and/or activity of one or more of the proteins selected from the group consisting of FGFR, SOS, GRB2, RAS, RAF, MEK and MAPK, and/or means inhibiting the nodal/activin/TGFbeta/SMAD2/3 signalling pathway, and/or the BMP/GDF/SMAD1/5/8 signalling pathway and, optionally, pluripotent cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087417-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018208836-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11702629-B2 |
| priorityDate | 2011-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 701.