| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e9aee13868bfedebe2df1f13cda5490 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-452
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-452
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 |
| filingDate |
2010-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a957677fdfcd50fff1f3b083d14eab3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd7a4576c6dec7e24e9055c5d705a86e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef9b915793da68f8c207dd202b928059
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbe6ad61d699a7727fc0b7b6e8da9c92 |
| publicationDate |
2012-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2489655-A1 |
| titleOfInvention |
Process for preparation of diethylenetriaminepentaacetic acid derivatives, and diethylenetriaminepentaacetic acid derivatives |
| abstract |
The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I):n nwherein R 1 to R 5 are independently C 1-6 alkyl groups; ncomprising the steps of: nreacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent; nremoving the excess halogenated ally compound (III); and nreacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent. |
| priorityDate |
2009-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |