http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2486002-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e459b6d9cc66efbd6417c94813588e27 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-54 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-36 |
filingDate | 2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16e22a9d1567a8831e97d825ec8f285e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a53b4c337560b32e1c2b0ad06bd342f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e5a5e87903299c481f1e7a54912acb |
publicationDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-2486002-A1 |
titleOfInvention | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
abstract | The invention relates to compounds of Formula (I): (A') x -(A)-(B)-(Z)-(L)-C(=O)NH 2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A'), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A') is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is -NH-; and (L) is -(CH 2 ) m CR 1 ,R 2 -, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R 1 and R 2 are each independently hydrogen or C 1 -C 6 alkyl; provided that, if (L) is -CH 2 - or -CH(CH 3 )-, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases. |
priorityDate | 2009-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1632.