| abstract |
Compounds of formula I : including any possible stereoisomers thereof, wherein: R 1 is hydrogen, -C(=O)R 6 or -C(=O)CHR 7 -NH 2 ; R 2 is hydrogen; or C 1 -C 6 alkyl or phenyl, either of which is optionally substituted with 1, 2 or 3 substituents each independently selected from halo, C 1 -C 6 alkyl, C 2 -C 6 -alkenyl and C 1 -C 6 alkoxy, hydroxy or amino, or R 2 is naphtyl; or R 2 is indolyl, R 3 is hydrogen, Ci-C6alkyl, benzyl; R 4 is hydrogen, Ci-C6alkyl, benzyl; or R 3 and R 4 together with the carbon atom to which they are attached form C 3 -C 7 Cyclo- alkyl; R 5 is C 1 -C 10 alkyl, C 3 -C 7 -cycloalkyl, benzyl, or phenyl, any of which being optionally substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C 1 -C 6 alkoxy, amino, mono- and diC 1 -C 6 alkylamino; R 6 is C 1 -C 6 alkyl; R 7 is C 1 -C 6 alkyl; R 8 is hydrogen or halogen; or a pharmaceutically acceptable salt or solvate thereof are useful in the prophylaxis or treatment of HCV infections. |