| abstract |
The invention relates to a compound of formula (I): wherein : • ALK is a (C 1 -C 6 )alkylene group; • X 1 et X 2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O) n (n=0,1 or 2) or O-; • R and R' are independently H or a (C 1 -C 6 )alkyl group; • I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; • j is an integer corresponding to 1 when X 2 is -CH=CH- and 2 when X 2 is not -CH=CH-; • Z b is a simple bond, -O- or -NH- and R b is H or a (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, aryl, heteroaryl or (C 3 -C 7 )heterocycloalkyl group; or Z b is a single bond and R b is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells. |