http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2478108-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa833f156f24311238f55730cd3c9e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2010-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2895b7503c315f28088fb724508db2ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cedd5d88d15c9bab84125840871191c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dd8776d8e85d95fbb3ec00fba380914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e460c0642cc913d77396cc827ad666b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daa0ade8fb0eb0cbfaaf2bcb2a24c9bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_460b6745260e683a3fd89067cf5fe9f3 |
| publicationDate | 2012-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2478108-A2 |
| titleOfInvention | Products and methods for enhanced transgene expression and processing |
| abstract | Disclosed are methods and eukaryotic host cells for transgene expression. The cells may be treated and/or modified to increase homologous recombination (HR), decrease non homologous end joining (NHEJ) and/or to enhanced a HR/NHEJ ratio in said cell. Such cells can be transfected with vectors comprising the transgene, which advantageously integrates into the genome of the cell to form a concatemeric strucutre which may comprise more than 200 transgene copies. Certain expression enhancing elements such as MARs are advantageously provided to further enhance and/or facilitate transgene expression. Disclosed is also a recombinant eukaryotic host cell, in particular a non-primate host cell, comprising a transgenic sequence encoding a protein and/or a RNA, in particualr a primate protein and/or RNA, involved in translocation across the ER membrane and/or secretion across the cytoplasmic membrane. |
| priorityDate | 2009-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1307.