| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3fab15895eb59644225598b1c9b9aea |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate |
2010-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ffe33f60cbb0c9a146571fabd5c491f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_606e0f4405d0b91b661cb73f32c42214
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c4098f7a97f96d0752a186b66051062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0db530c1c3bf792fa0fe5c887faea5b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98f540506b68b6240809ad3cc5a62d71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc683a9b1ddd6fedf19b5bf9b020918c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8ad76026455cc322bf61696b3f50d5 |
| publicationDate |
2012-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2476676-A1 |
| titleOfInvention |
S-5-substituent-n-2'-(thiophene-2-yl)ethyl-tetralin-2-amine or chiral acid salts thereof and use for preparing rotigotine |
| abstract |
The chiral compound S-5-substituted-N-2-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2'-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1 ) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N,2'-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2'-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2 ). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5 ). |
| priorityDate |
2009-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |