| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca61e4db63122e1293d328faa02cc379 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 |
| filingDate |
2010-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8ffc31b04bfaeb8fc89b28b66ec2684
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_296b0596e23c8c535e8524f16bac88eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caf42ec959570bdc861d257c2360220a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38ce737f59a883aa5a6daf6d3f780fcb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43b17a42b4f1a97d2b03b42cfdcdd5a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_621e2d609977738c89e2a7d6ec2df7f3 |
| publicationDate |
2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2442802-A1 |
| titleOfInvention |
Methods and compositions for increasing trichogenic potency of dermal cells |
| abstract |
Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay TM .The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation. |
| priorityDate |
2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |