http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2432497-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9adac5330984eb90146d4b9703816b56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b41b6aa7bad4413eabdc69f31f34557a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22c9432b8955bdc82a658bf5901e17f0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01034 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate | 2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb672f00eb2ae0bab4cd578d2d8261a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa707f2eef86e1abf8e88121184cb83 |
| publicationDate | 2012-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2432497-A1 |
| titleOfInvention | Use of lipoprotein lipase (lpl) in therapy |
| abstract | The present invention relates to a lipoprotein lipase (LPL) therapeutic for use in: reducing the number and/or size of chylomicrons in a subject; redistributing triglycerides in chylomicrons to very low-density lipoprotein (VLDL) in a subject; or increasing clearance of chylomicron remnants in a subject. Further, the invention relates to An LPL therapeutic suitable for use in the invention may be selected from the group consisting of: a) an LPL protein with an amino acid sequence as shown in SEQ ID NO: 3 or SEQ ID NO: 4, or a derivative of either thereof; b) an LPL protein with an amino acid sequence which comprises a contiguous segment having at least 90% sequence identity to SEQ ID NO: 3 or 4 when optimally aligned which has equal or greater LPL activity than a protein under a), or a derivative thereof; or c) a nucleic acid encoding a) or b), or a derivative thereof. |
| priorityDate | 2009-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 209.