Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B63-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 |
filingDate |
2009-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e09f794e1f4bc08e3eb2d4e3d957a05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a73726c157d976dcd5f2e2185982e70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e81b2c5f3d50ba50fe5a28ae87d69c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85035d966e8d547f289a6408d359bdb |
publicationDate |
2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-2423187-A1 |
titleOfInvention |
PROCESS FOR PRODUCTION OF N-ALKOXYCARBONYL-tert-LEUCINES |
abstract |
A high quality N-alcoxycarbonyl-tert leucine can be efficiently and stably produced with an easy procedure by reacting tert-leucine with an N-alcoxycarbonylating agent in the presence of water, wherein the use amount of the N-alcoxycarbonylating agent is not less than 0.90 times by mole and not more than 1.00 times by mole relative to the tert-leucine, with maintaining the pH of the reaction mixture in the range of not less than 9 and not more than 13 using a basic agent. In addition, an N-alcoxycarbonyl-tert-leucine can be efficiently extracted from the basic aqueous solution thereof under a mild condition using a water-immiscible solvent by mixing a hydroxide. Furthermore, the two crystal forms of N-butoxycarbonyl-tert-leucine can be controlled by adjusting the water amount in crystallization step, and the compound can be stably produced in an industrial production. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822304-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11193157-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9714439-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3510016-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10604781-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10196667-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019276391-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394551-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9080192-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018096484-A1 |
priorityDate |
2009-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |