| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_376837b4e71590b96d29c40a6bd55073 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-46 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0671
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3621 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12 |
| filingDate |
2010-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49f93732918d68d495503ea3af64d525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4afd703101dcc77ae4b737eddb7d2da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff812512b56b501f6e715e419b1d08d1 |
| publicationDate |
2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2421954-A1 |
| titleOfInvention |
Differentiated human liver cell cultures and their use in bioartificial liver systems |
| abstract |
The present invention concerns human hepatocyte cell line cultures and their use in bioartificial liver (BAL) systems. These systems are used to treat subjects suffering from liver failure to temporarily compensate for loss of hepatocellular function and generally comprise a bioreactor loaded with functional liver cells. Until now, it has been problematic to acquire cells with a broad spectrum metabolic functionality, resembling that of freshly isolated human hepatocytes, to the extent that they are in fact suitable for successful clinical BAL application The present inventors have managed to develop human hepatocyte cell line cultures that display broad-spectrum metabolic functionality such as to render them particularly suitable for effective clinical BAL application. |
| priorityDate |
2009-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |