http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2420562-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53aa3db371158a4b65472be0ccc1ba26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-747 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 |
| filingDate | 2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_375cd7414a3ced9b2e2d8c9d55294d7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_684ba88b5a3ea461a900560b5b4b5b11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8420936db0559d574d27cb87cf159b2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e6b6169947d9b91d5e293648255fe62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d368bf580a11ab31c209d0bfdef1c0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e50286cbbf49bfb0c77cc73f9c5700dc |
| publicationDate | 2012-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2420562-A1 |
| titleOfInvention | Lactic acid bacterium mutated into obligatory anaerobe, method for constructing same, and expression vector functioning in obligatory anaerobic lactic acid bacterium |
| abstract | Provided are: an obligatory anaerobic lactic acid bacterium expected as being usable as a safe remedy for a disease under an anaerobic environment, such as solid tumor, and a gene transport support, which is no danger of exerting side effects in a normal tissue; a method for constructing the same; and an expression vector which is useful in the construction method. The aforesaid obligatory anaerobic lactic acid bacterium is characterized by having been artificially mutated from a facultative anaerobe into an obligatory anaerobe, and being further transformable by an expression vector carrying a gene, which expresses an active protein useful in treating a disease under an anaerobic environment, transferred thereinto. The aforesaid expression vector is characterized by being an expression vector capable of functioning in an obligatory anaerobic lactic acid bacterium, which contains a plasmid replication protein gene(Rep)originating in a lactobacillus, a secretion signal sequence (PslpA-SSartP) consisting of an s-layer gene promoter originating in a lactobacillus and a PrtP protein secretion signal originating in a lactobacillus, and one or more kinds selection marker genes. Thus, it is possible to provide a remedy for a disease under an anaerobic environment and a microbial gene transport support which are highly safe and excellent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104471057-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2844736-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104471057-B |
| priorityDate | 2009-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 357.