| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ae7bc470b590116f17769a5b53f38cc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-593
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-595
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4172 |
| filingDate |
2010-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5b86fbc74fdbf9ed918a16232e29bf3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0de6be79e1eaf275e1297d5efd12db0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e02d90e365d547e10c72fd570720d64 |
| publicationDate |
2011-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2387999-A1 |
| titleOfInvention |
Histidine-containing solution for transfection and/or injection of nucleic acids and uses thereof |
| abstract |
The present invention is directed to a solution for transfection and/or injection containing at least one nucleic acid (sequence) and (free) histidine in a concentration of about 1 to about 25 µM. The present invention is also directed to the use of such histidine-containing solutions for transfection and/or injection of nucleic acid(s) (sequences), in particular for improvement of the transfection efficiency and/or endosomal release of nucleic acids. It is also directed to pharmaceutical compositions comprising such an inventive solution and its use as a medicament and/or for the prophylaxis, the treatment and/or the amelioration of various diseases as mentioned herein, e.g. by vaccination. The present invention is also directed to a method for transfection of a cell or an organism utilizing these inventive solutions and pharmaceutical compositions and to kits, comprising the inventive solution or pharmaceutical compositions thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035659-A1 |
| priorityDate |
2010-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |