| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11C3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-649
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-716
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-231
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-333 |
| filingDate |
2010-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebdb82165cc85adfa6fc1947595bcf56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b0142b2d1908c6006b9db60b1329da6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33fbf4c28d80a3b9e5d31e49d0f82e81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e59c5b55db7732f53fd5387357fce9e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17ffc75103005b2fc0cf8b27746822ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc3a50c2d8844236c4d80097ed04e750
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80bd35b577267a44b00f5042e6f40432 |
| publicationDate |
2011-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2379175-A1 |
| titleOfInvention |
A process for preparation of hexadecyl cis-9-tetradecenoate and hexadecyl cis-10-tetradecenoate |
| abstract |
Hexadecyl cis -9-tetradecenoate commonly known as Cetyl myristoleate (CMO) is being used for the treatment of osteoarthritis and other joint inflammatory diseases, cis -9- Tetradecenoic acid ( cis -9-myristoleic acid) is the main precursor for the preparation of CMO. As there are limited natural plant sources for cis-9-tetradecenoic acid, the present invention aimed at the synthesis of cis -9-tetradecenoic acid methyl ester from oleic acid methyl ester. As oleic acid is not available in pure form, this has to be isolated from oleic acid-rich oils like olive oil. cis - 10-Tetradecenoic acid methyl ester, an isomer of cis -9-tetradecenoic acid was also prepared from undecenoic acid methyl ester, a derivative of castor oil. Undecenoic acid is easily available commercially in pure form. Hexadecyl cis -9-tetradecenoateand hexadecyl c/s-10-tetradecenoate were prepared by enzymatic transesterification of cis -9-tetradecenoic acid methyl esterand cis -10- tetradecenoic acid methyl ester with 1-hexadecanol (cetyl alcohol) respectively. Both the isomers of cetyl myristoleate were evaluated for anti arthritis, blocking inflammation and reduction of adjuvant-induced arthritis in rats. |
| priorityDate |
2009-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |