http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2376099-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_658df3b9d24eb5224b37aaf605741db6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-65 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcbaf0d8ff1a66ae5d8442e841847a70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23bb7518da68e1a56fa01ac7826d8ea0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4f445f6d495f8e8fd52b9154f3a023a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58e634530051ae89c1c659a6cc88d1c6 |
| publicationDate | 2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2376099-A1 |
| titleOfInvention | Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor |
| abstract | Insulin-like growth factor analogs are disclosed wherein substitution of the IGF native amino acids, at positions corresponding to positions B 16 and B 17 of native insulin, with tyrosine and leucine, respectively, increases potency of the resulting analog at the insulin receptor by tenfold. Also disclosed are prodrug and depot formulations of the IGF analogs, wherein the IGF analog has been modified by the linkage of a dipeptide to the analog through an amide bond linkage. The prodrug and depot formulations disclosed herein have extended half lives of at least 2 hours, 10 hours, and more typically greater than 20 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability. |
| priorityDate | 2008-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 916.