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filingDate 2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cfcaca4dd85fe9926443e812dfde722
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publicationDate 2011-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2372347-A1
titleOfInvention Method to increase the number of detectable photons during the imaging of a biological marker
abstract The present invention relates a method to determine the presence of a photon producing biological marker in a cell, tissue or organism of interest. The method is based on Fluorescence by Unbound Excitation from Luminescence (FUEL) and comprises the steps of na) providing conditions suitable for the biological marker to produce at least one first photon by luminescence nb) providing a FUEL probe pair-upper (FPP-U) disposed in proximity to the cell, tissue or organism, wherein the at least one first photon of step a) excites the FPP-U, which emits at least one second photon. nThe FPP-U may be selected from the group of quantum dots, carbon nanotubes, fluorescent proteins, diamond nanocrystals, and metalloporphyrins. This method is characterized in that said biological marker and said FPP-U are not bound and in that each of the at least one second photon (s) are of a longer wavelength than each of the at least one first photon (s).
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