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publicationDate 2011-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-2363414-A2
titleOfInvention Site-directed modification of FVIII
abstract This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
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