| abstract |
The present invention provides a method of enhancing the survival of transplanted DA neurons, in particular a method comprising nobtaining a neural progenitor cell from a pluripotent stem cell culture or a cell differentiated from the neural progenitor cell; and ninducing an expression of a polypeptide selected from the group consisting of GDNF, BDNF, Nurr-1 and Lmx 1 b in the neural progenitor cell or the cell differentiated from the neural progenitor, as well as a neural cell having been ex vivo differentiated from a pluripotent stem cell and related aspects. |