http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2345737-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca0e71aa4f9cdaafbf35ab0f3d0fd48f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6845 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2010-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c1ba423474bdf24030c8283cef0fedf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6988f69adeb6c0b93b545a202dcf159d |
| publicationDate | 2011-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2345737-A1 |
| titleOfInvention | Method for identifying inhibitors of protein translocation |
| abstract | The present invention relates to a method for identifying an inhibitor of protein translocation comprising the steps of: na) providing a nucleic acid molecule encoding a polypeptide comprising a translocation signal domain and/or a transmembrane domain and having no stop codon in the reading frame of said polypeptide, nb) translating in vitro the nucleic acid molecule of step a) into a ribosome bound nascent polypeptide by contacting said nucleic acid molecule with an in vitro translation system comprising ribosomes, nc) optionally contacting the ribosome bound nascent polypeptide of step b) with a compound releasing the polypeptide from the ribosome and isolating said released polypeptide, nd) incubating at least one test compound or a library of test compounds ni) with the ribosome bound nascent polypeptide of step b) or optionally nii) with the isolated polypeptide of step c), n ne) isolating the ribosome bound nascent polypeptide or optionally isolated polypeptide of step d) and identifying the test compound bound to said polypeptide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10906937-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3774849-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10266567-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016139667-A1 |
| priorityDate | 2010-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 341.