| abstract |
The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof. |