http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2320917-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37b416a8c0d2b0f1c3d6026d932027af |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-00 |
| filingDate | 2009-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b607502fea43954dc7ccc57ed450b3a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba6f65a7ec30c304418d61e29e25502e |
| publicationDate | 2011-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2320917-A1 |
| titleOfInvention | Methods of preventing, arresting or reversing tumourigenesis and of identifying compounds capable of the same |
| abstract | Disclosed are methods of preventing, inhibiting, arresting or reversing tumorigenesis in a cell and of inducing programmed cell death (apoptosis) in a tumor cell. The methods include altering the formation of a complex between RUNX3, or a functional fragment thereof, and at least one of (i) beta-catenin, or a functional fragment thereof, and (ii) a member of the TCF/LEF transcription co-factor family. Disclosed are also methods of diagnosing the risk of tumorigenesis in a cell and of diagnosing the risk of developing a neoplasm in a subject. Such method includes assessing the formation of a complex as defined above. An in-vitro method of identifying a compound capable of altering the formation of the afore defined complex is also disclosed. The method includes contacting the components that form the above complex with each other and adding a compound to the test tube suspected to modulate said complex formation. |
| priorityDate | 2008-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 868.