| abstract |
Selective androgen receptor modulator (SARM) compounds having the formula Ia:n nwherein nX nis O; nT nis OH, OR, -NHCOCH 3 , or NHCOR; nZ nis CN; nY nis CF 3 , I, Br, Cl, CN, C(R) 3 or Sn(R) 3 ; or Z and Y together with the benzene ring to which they are attached form a fused bicyclic carbocyclic or heterocyclic ring system; Q is F, Cl, Br or I; nR nis alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH 2 F, CHF 2 , CF 3 , CF 2 CF 3 , aryl, phenyl, F, Cl, Br, I, alkenyl or OH; and nR 1 nis CH 3 , CH 2 F, CHF 2 , CF 3 , CH 2 CH 3 , or CF 2 CF 3 ; n ncan be used in the treatment of osteoporosis, osteopenia, low bone mass, bone fragility, osteomalacia, or any combination thereof, a male subject having an Androgen Decline in Aging Male (ADAM)-associated condition, or a female subject having an Androgen Decline in Female (ADIF)-associated condition, in a subject. |