abstract |
The present invention concerns the use of a nucleic acid construct comprising: n(a) a first polynucleotide region encoding a suicide gene, said suicide gene being capable of converting a prodrug to a toxic compound and n(b) a second polynucleotide region comprising a cis regulatory element capable of directing expression of said suicide gene in angiogenic cells and an endothelial specific promoter, n nfor the manufacture of a medicament for down-regulating angiogenesis in a subject in need thereof. |