http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2289870-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1224e3c07b7cc5684ee81d9e1e5ee15c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-32 |
| filingDate | 2009-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53c79428cb8c2cf8506b5e8eb6985ff9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bd1f5ba60eda75f67fa357113855b54 |
| publicationDate | 2011-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-2289870-A1 |
| titleOfInvention | Method for purifying 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide, an intermediate in the preparation of non-ionic X-ray contrast agents |
| abstract | This invention relates to the preparation of non-ionic X-ray contrast agents, iohexol, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in the industrial preparation of these non-ionic X-ray contrast agents. In particular, it relates to a method for significantly removing ABA monomethylester and ABA dimer from ABA by hydrolyzing ABA under a pH between 12 to 13 in an aqueous medium to convert ABA monomethylester to ABA monoacid, before the iodination reaction of ABA. |
| priorityDate | 2009-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.