| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bc5292a07e34d16eb1d033a16d3aec3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate |
2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d78ca2ce88dab0bde493b0b617102009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaed836f9d0fbfeae6a4e8415424384a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb7a837b194b67456928b438f1cc52c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bf4a61a9721c677eb302394819b4ca5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_469a6bc551083514daf0599c14a849b8 |
| publicationDate |
2011-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-2288378-A1 |
| titleOfInvention |
Pharmacological targeting of vascular malformations |
| abstract |
Disclosed herein are compositions and methods for decreasing vascular permeability in a blood vessel and treating or preventing conditions associated with defects or injuries of vascular endothelium. For example, the disclosed compositions and methods can be used to treat a vascular dysplasia such as cerebral cavernous malformation (CCM). These methods relate generally to the use of compositions that inhibit RhoA GTPase levels or activity, such as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. |
| priorityDate |
2008-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |